A short overview of Lung-on-Chip systems. The use of the alveolar-capillary barrier in human medicine by Emma Thomée.
Author: Emma Thomée*, PhD candidateEmail: emma.thomee@elvesys.com 1. Introduction into lung-on-a-chip microfluidic systems Organ-on-chip technology provides unique opportunities to study lung physiology and pathophysiology in vitro. The first lung-on-a-chip platforms emerged almost 10 years ago, and significant progress has since been made in terms of both biological and engineering complexity. Here, we describe one of the most sophisticated lung-on-a-chip systems in terms of biological complexity [1] that model the alveolar-capillary barrier, in order to present the current knowledge on the topic. 2. Structure and function of the human lung Organ-on-chip technology provides unique opportunities to study lung physiology and pathophysiology in vitro. The first lung-on-a-chip platforms emerged almost 10 years ago, and significant progress has since been made in terms of both biological and engineering complexity. Here, we describe one of the most sophisticated lung-on-a-chip systems in terms…