{"id":1064,"date":"2022-02-02T14:25:17","date_gmt":"2022-02-02T13:25:17","guid":{"rendered":"https:\/\/mami.u-strasbg.fr\/?page_id=1064"},"modified":"2022-02-02T14:26:58","modified_gmt":"2022-02-02T13:26:58","slug":"sarah-koster","status":"publish","type":"page","link":"https:\/\/mami.u-strasbg.fr\/index.php\/sarah-koster\/","title":{"rendered":"Sarah K\u00f6ster"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"1064\" class=\"elementor elementor-1064\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a0464a8 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a0464a8\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c4f2196\" data-id=\"c4f2196\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e73a4a6 elementor-position-left elementor-vertical-align-top elementor-widget elementor-widget-image-box\" data-id=\"e73a4a6\" data-element_type=\"widget\" data-widget_type=\"image-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<div class=\"elementor-image-box-wrapper\"><figure class=\"elementor-image-box-img\"><a href=\"https:\/\/www.uni-goettingen.de\/en\/91107.html\"><img decoding=\"async\" width=\"517\" height=\"591\" src=\"https:\/\/mami.u-strasbg.fr\/wp-content\/uploads\/2022\/02\/Koester_0515_3_cut_small.jpg\" class=\"attachment-full size-full\" alt=\"\" loading=\"lazy\" \/><\/a><\/figure><div class=\"elementor-image-box-content\"><h3 class=\"elementor-image-box-title\"><a href=\"https:\/\/www.uni-goettingen.de\/en\/91107.html\">Sarah K\u00f6ster<\/a><\/h3><p class=\"elementor-image-box-description\">Prof. Dr. Sarah K\u00f6ster <br>\n\nGeorg-August-Universit\u00e4t G\u00f6ttingen<br>\n\nInstitute for X-Ray Physics<br><\/p><\/div><\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bf4e1c9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bf4e1c9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2de8a7b\" data-id=\"2de8a7b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b57d485 elementor-widget elementor-widget-heading\" data-id=\"b57d485\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Title: Mechanics of cytoskeletal filaments and networks<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a28f76b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a28f76b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5301a75\" data-id=\"5301a75\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-0edbf05 elementor-widget elementor-widget-text-editor\" data-id=\"0edbf05\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p><span lang=\"en-DE\"><strong>Abstract:<\/strong> Mechanical properties of eukaryotic cells are to a great part determined by the cytoskeleton, a composite biopolymer network composed of three filament systems \u2013 intermediate filaments, F-actin and microtubules \u2013 along with cross-linkers and molecular motors. Among the three filament types, Intermediate filaments are the most flexible and the most extensible ones, with an intriguing non-linear behavior. It has been shown previously that the presence of intermediate filaments in a cell has an influence on cell mechanics. Here we unravel different contributions to network properties and cell mechanics, such as the assembly kinetics and mechanical properties of the individual filaments (in particular at high strains), filament-filament interactions, and network rheology. To explain our experimental results on molecular grounds, we design models that include the strictly hierarchical build-up of the filaments (with multiple alpha-helical domains arranged in parallel) and non-equilibrium transitions between folded and un-folded states. Taken together experiments and modelling indicate that intermediate filaments serve as \u201csafety belts\u201d and shock absorbers\u201d for the cell, thus avoiding damage at high, fast impact while maintaining flexibility (e.g. during cell motility).<\/span><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Sarah K\u00f6ster Prof. Dr. Sarah K\u00f6ster Georg-August-Universit\u00e4t G\u00f6ttingen Institute for X-Ray Physics Title: Mechanics of cytoskeletal filaments and networks Abstract: Mechanical properties of eukaryotic cells are to a great part determined by the cytoskeleton, a composite biopolymer network composed of three filament systems \u2013 intermediate filaments, F-actin and microtubules \u2013 along with cross-linkers and molecular [&hellip;]<\/p>\n","protected":false},"author":4,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":[],"_links":{"self":[{"href":"https:\/\/mami.u-strasbg.fr\/index.php\/wp-json\/wp\/v2\/pages\/1064"}],"collection":[{"href":"https:\/\/mami.u-strasbg.fr\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/mami.u-strasbg.fr\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/mami.u-strasbg.fr\/index.php\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/mami.u-strasbg.fr\/index.php\/wp-json\/wp\/v2\/comments?post=1064"}],"version-history":[{"count":3,"href":"https:\/\/mami.u-strasbg.fr\/index.php\/wp-json\/wp\/v2\/pages\/1064\/revisions"}],"predecessor-version":[{"id":1069,"href":"https:\/\/mami.u-strasbg.fr\/index.php\/wp-json\/wp\/v2\/pages\/1064\/revisions\/1069"}],"wp:attachment":[{"href":"https:\/\/mami.u-strasbg.fr\/index.php\/wp-json\/wp\/v2\/media?parent=1064"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}